Background: Presynaptic forms of congenital myasthenic syndromes (CMS) due to pathogenic variants in SLC18A3 impairing the synthesis and recycling of acetylcholine (ACh) have recently been described. SLC18A3 encodes the vesicular ACh transporter (VAChT). modulating the active transport of ACh at the neuromuscular junction. and homozygous loss of VAChT leads to lethality. https://spencertifieders.shop/product-category/electronics/