Background Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations. loss of heterozygosity (LOH). and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers. https://www.roneverhart.com/Cocomelon-Outdoor-Adventures-with-JJ-Audio-Play-Character/