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RB depletion is required for the continuous growth of tumors initiated by loss of RB.

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The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation. RB has been extensively studied. but its mechanisms of action in normal and cancer cells remain only partly understood. Here. https://www.roneverhart.com/MLB-Pop-Vinyl-Figure-Khris-Davis-Oakland-A-s-27/
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